litaba

Joalo ka sebopeho sa masapo a lihlahisoa tse ngata tsa tlhaho tse nang le melemo le lithethefatsi (joalo ka dexamethadine ea khohlela), boitšoaro bo ka fumaneha ho tsoa khubung ea bohlokoa bohareng ba 1-benzyl octahydroisoquinoline ka mekhoa e meraro ea lik'hemik'hale. Mekhoa ea mantlha ea mahareng e kenyeletsa karohano ea khale, asymmetric catalytic hydrogenation of transition iron and desematization of cyclohexamine oxidase and boramine, empa mekhoa ena ka kakaretso e na le likotsi tse kang ho se sebetse hantle, theko e phahameng ea tlhahiso, moruo o fokolang oa atomiki kapa tšilafalo e mpe ea tikoloho.

Setsi sa Tianjin sa biotechnology ea indasteri, Setsi sa thuto ea Chaena sa thuto ea mahlale Zhu Duiming, Wu Qia o etella pele sehlopha sa lik'hemik'hale le limela tse tala, a sebelisa Imine Reductase (Imine Reductase, IRED) phokotso ea khetho ea antipodal ea khethiloeng ea alpha, beta unsaturated Imine (1 - benzyl six hydrogen isoquinoline derivatives), litokisetso tse atlehileng tsa tse tsoang 1 - benzyl tse robeli tsa hydrogen isoquinoline, hobane sehlopha sena sa motsoako se rarahaneng se fana ka mokhoa o sebetsang oa tlhahlobo ea tlhaho ea tlhaho.

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Phuputsong ena, laebraring ea imine reductase e ile ea hlahlojoa ka ho sebelisa karolo e ka pele ea dextromethorphan, mme ho ile ha fumaneha hore li-enzyme tse peli li bonts'itse boemo bo holimo le bo tlatselletsang, ka ts'ebetso ea enantiomer ho fihlela ho 98% (S) le>. ts'ebetso e ne e le 5.4 × 10-2 le 24.1 × 10-2 s-1 mm-1, ka ho latellana.Le motheong ona, karabelo ea tekanyo ea laboratori e thehiloe, 'me tlhahiso ea karohano ea sehlahisoa e ne e le 74% le 80% ka ho latellana. Kamora nako, enzyme e nang le maemo a phahameng a sepakapaka e ile ea fumanoa ha ho lokisetsoa lintho tse tsoang sebakeng se fapaneng sa p-boemo le boemo ba litekanyetso tsa pele tsa sebaka, tse ka fumanang tlhahiso e phahameng ea tlhahiso le karohano bakeng sa likarolo tsohle tse robeli, mme tsa ba le menyetla e meholo ea tlholisano holima mekhoa ea khale ea li-complication tsena.

Patlisiso e ts'ehelitsoe ke motheo oa naha oa mahlale oa China (21778072) le khomishene ea mahlale le mahlale a tianjin (15PTCYSY00020 le 15PTGCCX00060). Patlisiso e sa tsoa hatisoa koranteng ea Advanced catalysis & catalysis, 'me e se e khethiloe e le Sehloho se Hlooho sa bicatalysis .Yao peiyuan, mofuputsi ea kopaneng setsing sa mahlale sa tianjin, le xu zefei, seithuti se tsoang sekolong, ke bangoli ba etellang pele ba pampiri eo.


Nako ea poso: Mots'eanong-28-2020